Outreach

Human neurons integrate as single cells into the mouse cortex where they display human-like prolonged development and functionally integrate into the visual circuits of the mouse brain.

For more information, see Linaro et al., Neuron

Pierre Vanderhaeghen gave a talk at the College de France. You can watch a recording here (in French).

The Axa Foundation supports or research and produced this instructive animation video on stem cells

In this video, Ira Espuny-Camacho and Pierre Vanderhaeghen describe how human pluripotent stem cells can be turned into cortical pyramidal neurons, mimicking key aspects of human corticogenesis. Most strikingly, they show that these human neurons can be transplanted successfully in the mouse neonatal brain, where they integrate specifically and functionally like endogenous cortical neurons. These data provide a unique framework to model human cortical development in health and disease, both in vitro and in vivo. 

AXA interviews Pierre Vanderhaeghen on his research and motivations